Carbon Dioxide-enhanced oil recovery (CO2-EOR) is a tertiary oil extraction technology used after primary and secondary techniques have been used at an oil field. CO2-EOR operators use alternating injection schemes of CO2 and water to reduce the viscosity of crude oil, allowing recovery of a resource that would be otherwise unrecoverable. The primary objective of CO2-EOR is to produce additional crude oil from a mature oil field, but CO2-EOR also sequesters CO2. The National Energy Technology Laboratory's LCA model of CO2-EOR is a cradle-to-grave model that accounts for the greenhouse gas emissions and other environmental burdens from CO2-EOR systems. A process-based approach uses parameters that allow comparisons of different operating conditions and characterization of uncertainty. The model leverages existing NETL life cycle data to account for environmental burdens upstream and downstream from the CO2-EOR site, including natural dome and several anthropogenic sources CO2, petroleum refining, and combustion of finished petroleum products such as gasoline or diesel.